Human hair fibers structure consists of cuticle, cortex and medulla. The cuticle constitutes about 15% by weight of the hair and consists of overlapping layers of cells, similar to a system of scales, with high content of cysteine. It provides a protective character to the hair fiber. The cortex is the middle region of the hair being responsible for the strength, elasticity and hair color. It is composed of several cell types and represents about 80% of the weight of the hair.
Hair is composed of approximately 65% to 95% protein.The majority of the proteins present in human hair correspond to keratin and keratin-associated proteins. Keratins and mainly keratin-associated proteins have high sulfur content, present in the cysteine amino acid. The presence of sulfur is essential to the hair structure, as it allows the formation of disulfide bonds between amino acids of the polypeptide chains, due to oxidation of cysteine. The existence of these bonds is largely responsible for the structure and texture of the hair.
SH-Oligopeptide-78 is based in the structure of keratin and keratin associated proteins and is a synthetic peptide sequences analogous to keratin proteins, it does not rely on hydrophobic binding domains and/or carbohydrates, but disulfide bonds. SH-Oligopeptide-78 contains amino acids with sulfur, specifically cysteine, which interacts with the hair and allows the formation of disulfide bonds that stabilize the keratinous fiber and protect the hair fiber.
SH-Oligopeptide-78 allows a resistance increase due to the presence of the cysteine-rich peptide, which leads to the resistance of the hair even after several rinsing.
SH-Oligopeptide-78 is capable to prevent the hair surface degradation and consequently, the hair treated with SH-Oligopeptide-78 has a longer life span.
Formulations with SH-Oligopeptide-78 ensure that the peptides can have a lasting fixation in the hair, improving the hair properties such as elasticity and strength.
Formulations with SH-Oligopeptide-78 allow hairs penetration and enrichment of the hair properties, such as elasticity, strength, appearance, resistance, repair damaged keratinous fiber, reduce eventual hair damage, as well as improve and change hair characteristics.
Formulations through the use of SH-Oligopeptide-78, allows the preparation of keratinous fiber damages, due to the high binding capacity of the keratin peptides, including through disulfide bridges.Formulations allow the dermo-cosmetic treatment of hair, chemically pre-treated or not.
Formulations with SH-Oligopeptide-78 after prolonged use, provide hair with soft, shiny, undamaged texture and with the desired features. SH-Oligopeptide-78 provides resistance to strength, toughness and elasticity to the hair. Therefore,SH-Oligopeptide-78 is particularly relevant for hair treatment, hair dying, hair perms, etc.
Formulations with SH-Oligopeptide-78 can be used in hair treatment, treatment of hair scalp diseases such as uncombable hair syndrome, for use as hair strengthener, for use as hair curl or uncurl agent,fixer of perms, hair coloring.
SH-Oligopeptide-78 can be applied to the hair in the form of aqueous or conventional preparation of shampoo or conditioner. It can also be in the form of lotion, foam, spray, gel, mask, serum, cream, elixir, oil, aerosol, formulation applied with or without subsequent rinsing.